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2017-4-24 16:03:50 | ʾȫ¥ |Ķģʽ
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ʶ沢DzܣΪʶҪ岻ʵֲ֡ش
1ֽ׶εĿƼˮƽǷпܴϱȥֱĹأѶ
𣺲ܡĿǰǵĿƼˮƽ󲿷ּ޷˥ˡ
ѶҪж޷ֿ˥Ϻ
һ޷ֿ˥ȥcellϷһƪThe Hallmarks of Aging[1]˥ϵı־ʵϣܽ˥ϵĸԭҲǣϸϣ޷ԭΪҪ˥ϣҪ
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ҽһ³ĵ˥ԭΪЩϰеļ޷˷ǻ鲻ȶԣgenomic instability, ̣telomere attrition,Ŵѧı䣨epigenetic alterations, ̬ɥʧloss of proteostasis, ӪӦʧderegulated nutrient sensing, 幦쳣mitochondrial dysfunction, ϸ˥ϣcellular senescence, ϸĽߣstem cell exhaustionϸϢı䣨altered intercellular communication
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Ϊʲôﲻ - ֪ûĻش

ɣ۾ڲ㡿
Ŀǰ޵Ҫ۵㣬һԳۣһǺ˼ޡ
ԳһͳѧۣΪļԳ8-10鶯
˼һϸʵϸķֻʮʮԺ󣬲ܲʲôϸҪ˥[2]۵ԹĿǰоõϸϵIMR90WI38ȣ60ǸϸͲˣĵ
ͨЩۣƲ120-150ңԺֻǶ΢
Ǿ˶䣬Ϊļʹǹ
ؼĵڶ
2ûпʵʶأƺڿ͵۹ʶԶͣ񹥿ǻʶ˼ά
УΪKֵ֮ǰʵֵһ
Ҫ򵥽һ£ĿǰʶͿԼĿǰĽչ
ȣΨ壬ΪһﶼʻرΪѧ - ֪ûĻش磬̼Ǹйأݿܸ״ټйأܸͰصȵȣǵʶΪʻڴԡ
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ԴԪЩԪ˴֮ʱ޿̲ڴŵźţÿһγһźţγǵʶ
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ÿһӣʹһʶAӴգۣBӴϲCӴ̫ˣϸˣ
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ͼһе˺˵һӣҪƫä[3]
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ͼΪ߷ֲͼͼΪƫäߵ߷ֲͼĴСǰʵʱġߵرγɵӺԭмǿӷֱɫɫ

ζţ˵ʶ͹ܻǴԣԵĻʽԪΪλͨźźŴݡ ôˣֻҪƽЩźŴݹ̣ôǾͿƽ˵ʶ

ô˷ܰɣֱѲѧңѧеʱ;ǣĿ̣̱21ٹ̣ԤҪ100ʱɡ
ĿǰѾʵʩļƻ
1ĿHuman Connectome ProjectԺNIH 2009ʼһ5ĿĿĿʹòͬԳҪǾϢ̬ܴŹɢŹEEGMEGΪ䣩ƳͬԹܡ
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2ƽ񾭼оƻơԼƻ201342ɰ°üƻּ̽ԹơԻȫͼտԴԼƷ
3ԹзƻʿɣѧԺںķǣͷص87зŶӹͬʵʩһĿƻʮʱ䣬ü조ģ͡ԣоԱ轫г8000Ƭøɨǽֻͼͬʱóģĺݣ󽫳ǧԪģγɾֲģͣװΪһתġ
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4йԼƻѻԺʾΪ¹ҹδչشƼĿ֮һʶԡԺģȫĿǰпԺľŸ׿Խ漰ҽѧΨһľϺԺġԿѧܼ׿Խġ
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Ŀǰ׶ΣһƽˣôOKˣǾͿģ˵ĴˣǵźAʾ㿴ɫBʾ㿴̫CʾԱȶߵƵģٽһxʾijijijxxʾijijijѧʲô֪ʶ
һȽϴֲڵӣ2013<Science>[4]T. HorikawaùԴŹ־Ը˯ʱĴԻ¼3˯һЩݣ˵ȣЩݷֳɴԼ20Ȼ3״̬¼ƳʱԻȽϣóÿԻ硣оԱĵԳѧϰʶЩԻ磬׼ȷʸߴ60%һdzdzԵģǿСƵʵ飬һdzҪ֤ݡ
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Ȼȫƽԣôǰһеȫģ˾Ϳˣһ˵һκξȫ
һȻôȫ԰ݸƵһµĴ¡ඥһǼźͨ·̣ǾͿתˣôǾˡ

butʱ˴ڵ˵ڵأxxooðһδ룬Ů̸ãһδ루ͼҲǿԴ뻯һźɵ缯壬ôDzǺڿ͵۹Ҫˣ


˳˵һ䣬ܶ˼ǻū˵Ļʶʵķߣ˵ΨһһֲȫݣvsСͬ˫̥
ȤĸλȥһԵĴһ˷ԭϣ˻ԭ - ѧ
1 Lpez-Otn C, Blasco M A, Partridge L, et al. The hallmarks of aging[J]. Cell, 2013, 153(6): 1194-1217.
2 Hayflick L. The limited in vitro lifetime of human diploid cell strains[J]. Experimental cell research, 1965, 37(3): 614-636.
3 Guo X, Jin Z, Feng X, et al. Enhanced Effective Connectivity in Mild Occipital Stroke Patients With Hemianopia[J]. Neural Systems and Rehabilitation Engineering, IEEE Transactions on, 2014, 22(6): 1210-1217.
4 Horikawa T, Tamaki M, Miyawaki Y, et al. Neural decoding of visual imagery during sleep[J]. Science, 2013, 340(6132): 639-642.
˽ԼƻԹ̵ģԹע
<a href="https://link.zhihu.com/?target=http%3A//www.humanconnectomeproject.org/" class=" wrap external" target="_blank" rel="nofollow noreferrer">Human Connectome Project | Mapping the human brain connectivity</a>
<a href="https://link.zhihu.com/?target=https%3A//www.humanbrainproject.eu/" class=" wrap external" target="_blank" rel="nofollow noreferrer">The Human Brain Project</a>



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