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ʶ沢DzܣΪʶҪ岻ʵֲ֡ش
1ֽεĿƼˮƽǷпܴϱȥֱĹأѶ
𣺲ܡĿǰǵĿƼˮƽּ˥ˡѶҪжֿ˥Ϻ
һֿ˥ȥcellϷһƪThe Hallmarks of Aging[1]˥ϵı־ʵϣܽ˥ϵĸԭҲǣϸϣԭΪҪ˥ϣҪ
ҽһ³ĵ˥ԭΪЩϰеļ˷ǻ鲻ȶԣgenomic instability, ̣telomere attrition,Ŵѧı䣨epigenetic alterations, ̬ɥʧloss of proteostasis, ӪӦʧderegulated nutrient sensing, 幦쳣mitochondrial dysfunction, ϸ˥ϣcellular senescence, ϸĽߣstem cell exhaustionϸϢı䣨altered intercellular communication
ϸ˽ƲΪʲôﲻ - ֪ûĻش
ɣ۾ڲ㡿
ĿǰҪ۵㣬һԳۣһǺ˼ޡ
ԳһͳѧۣΪļԳ8-10鶯
˼һϸʵϸķֻʮʮԺܲʲôϸҪ˥[2]۵ԹĿǰоõϸϵIMR90WI38ȣ60ǸϸͲˣĵ
ͨЩۣƲ120-150ңԺֻǶ
Ǿ˶䣬Ϊļʹǹ
ؼĵڶ
2ûпʵʶأƺڿ͵۹ʶԶͣǻʶ˼ά
УΪKֵ֮ǰʵֵһ
Ҫһ£ĿǰʶͿԼĿǰĽչ
ȣΨ壬ΪһﶼʻرΪѧ - ֪ûĻش磬̼Ǹйأݿܸ״ټйأܸͰصȵȣǵʶΪʻڴԡ
ԴԪЩԪ˴֮ʱ̲ڴŵźţÿһγһźţγǵʶ
ÿһӣʹһʶAӴգۣBӴϲCӴ̫ˣϸˣ
ͼһе˺˵һӣҪƫä[3]
ͼΪ߷ֲͼͼΪƫäߵ߷ֲͼĴСǰʵʱġߵرγɵӺԭмǿӷֱɫɫ
ζţ˵ʶܻǴԣԵĻʽԪΪλͨźźŴݡ ôˣֻҪƽЩźŴݹ̣ôǾͿƽ˵ʶ
ô˷ܰɣֱѲѧңѧеʱ;ǣĿ̣̱21ٹ̣ԤҪ100ʱɡ
ĿǰѾʵʩļƻ
1ĿHuman Connectome ProjectԺNIH 2009ʼһ5ĿĿĿʹòͬԳҪǾϢ̬ܴŹɢŹEEGMEGΪ䣩ƳͬԹܡṹͼס
2ƽоƻơԼƻ201342ɰ°üƻּ̽ԹơԻȫͼտԴԼƷ
3ԹзƻʿɣѧԺںķǣͷص87зŶӹͬʵʩһĿƻʮʱ䣬ü조ģ͡ԣоԱ轫г8000ƬøɨǽֻͼͬʱóģĺݣǧԪģγɾֲģͣװΪһתġģ
4йԼƻѻԺʾΪ¹ҹδչشƼĿ֮һʶԡԺģȫĿǰпԺľŸԽ漰ҽѧΨһľϺԺġԿѧܼԽġ
ϣ˼·
ĿǰΣһƽˣôOKˣǾͿģ˵ĴˣǵźAʾ㿴ɫBʾ㿴̫CʾԱȶߵƵģٽһxʾijijijxxʾijijijѧʲô֪ʶ
һȽϴֲڵӣ2013<Science>[4]T. HorikawaùԴŹ־Ը˯ʱĴԻ¼3˯һЩݣ˵ȣЩݷֳɴԼ20Ȼ3״̬¼ƳʱԻȽϣóÿԻ硣оԱĵԳѧϰʶЩԻ磬ȷʸߴ60%һdzdzԵģǿСƵʵ飬һdzҪ֤ݡ
Ȼȫƽԣôǰһеȫģ˾Ϳˣһ˵һκξȫ
һȻôȫݸƵһµĴ¡ඥһǼźͨ·̣ǾͿתˣôǾˡ
butʱ˴ڵ˵ڵأxxooðһδ룬Ů̸ãһδ루ͼҲǿԴ뻯һźɵ缯壬ôDzǺڿ͵۹Ҫˣ
˳˵һ䣬ܶ˼ǻū˵Ļʶʵķߣ˵ΨһһֲȫݣvsСͬ˫̥
ȤĸλȥһԵĴһ˷ԭϣ˻ԭ - ѧ
1 Lpez-Otn C, Blasco M A, Partridge L, et al. The hallmarks of aging[J]. Cell, 2013, 153(6): 1194-1217.
2 Hayflick L. The limited in vitro lifetime of human diploid cell strains[J]. Experimental cell research, 1965, 37(3): 614-636.
3 Guo X, Jin Z, Feng X, et al. Enhanced Effective Connectivity in Mild Occipital Stroke Patients With Hemianopia[J]. Neural Systems and Rehabilitation Engineering, IEEE Transactions on, 2014, 22(6): 1210-1217.
4 Horikawa T, Tamaki M, Miyawaki Y, et al. Neural decoding of visual imagery during sleep[J]. Science, 2013, 340(6132): 639-642.
˽ԼƻԹ̵ģԹע
<a href="https://link.zhihu.com/?target=http%3A//www.humanconnectomeproject.org/" class=" wrap external" target="_blank" rel="nofollow noreferrer">Human Connectome Project | Mapping the human brain connectivity</a>
<a href="https://link.zhihu.com/?target=https%3A//www.humanbrainproject.eu/" class=" wrap external" target="_blank" rel="nofollow noreferrer">The Human Brain Project</a>
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